![]() Stem cell therapy may yet prove to be a unique and effective approach for managing multiple sclerosis. Because of this, researchers are consistently searching for an approach that can help fight symptoms of MS. While people with multiple sclerosis don’t always have a decreased lifespan, the quality of their life can be decreased. As the disease progresses, patients become subject to increasingly intense symptoms. MS is a disease that affects the brain and spinal cord and, thus, the entire nervous system. doi: 10.21037/sci.2019.10.06.Multiple sclerosis (MS) is a degenerative disease that can cause a number of physical and mental symptoms. Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis. The researchers conclude hematopoietic stem cell and various MSC treatments result in “significant improvements in quality-of-life, neurologic disability, and functional scores,” among patients with MS.īejargafshe MJ, Hedayati M, Zahabiasli S, et al. Studies proposed hematopoietic stem cell transplantation “can prohibit MS disease progression for 4 to 5 years in 70% to 80% of patients.” However, “HNSCs are obtained from brain specimens of several fetal human donors from spontaneous miscarriages that occurred after the eighth week after conception…Due to ethical reasons and the lack of the same opportunity to make these cells, it is difficult to use them,” researchers said.Ī type of stem cell-based therapy developed for the treatment of hematological malignancies like lymphoma and leukemia has been explored in recent investigations. In comparison, human fetal-derived neural stem cells (HNSCs) can be considered one of the best treatments for patients with MS because they are the precursors of neuronal cells. In addition, umbilical cord-derived MSCs are attractive treatment options because they are extracted from easily attainable tissue, absent of any ethical dilemmas. ![]() ![]() The researchers determined adult adipose tissue stem cells are “one of the most suitable cells for MS treatment.” This is due to the fact that adipose tissue is easy to separate, produces a high volume of cells per unit area, and has relatively inexpensive extraction costs. Clinical studies also found that adipose-derived MSC therapy “is a safe method which improves MS disabilities, such as sexual problems and social activities,” in patients. The injection of bone marrow-derived autologous MSCs has been revealed to improve the disease’s severity, patients’ cognitive functions, and overall quality of life due to the cells’ neuroprotective and anti-inflammatory properties. The review analyzed the safety and efficacy of trials involving stem cells derived from these various sources. Stem cells can be easily isolated from different sources of the body, including peripheral blood, adipose and bone marrow tissues, umbilical cord blood, and placenta. For example, “Upon intravenous injection, MSCs are able to traffic into the brain lesions and improve the survival rate of brain cells.” Results also revealed that injection of MSCs decreases disease severity and improves quality of life in patients with MS. “MSCs are multipotent cells with high proliferative and self-renewal capacities, as well as immunomodulatory and neuroregenerative effects,” the researchers said.Īlthough the underlying cellular and molecular mechanisms of stem cell therapy in patients with MS is not understood, tirals have yielded encouraging results. However, clinical trial results point to the safety and efficacy of certain MSC therapies in modulating immune responses in patients with MS. Currently, there is no curative method for MS, nor is there an approved method for improvement of disease progression by repairing the damaged myelin. One of the main symptoms of myelin dysfunction is neurological disabilities. Patients develop MS when autoantibodies target the self-myelin antigens, causing demyelination. Several clinical trials have found mesenchymal stem cell (MSC) therapy effective in treating neural damage in patients with multiple sclerosis (MS), according to a review published in Stem Cell Investigation.
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